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Domperidone
(CAS RN:57808-66-9 Product Number:D4125)

Structure

Domperidone
Synonym 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one

General Information

Product Number D4125

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C22H24ClN5O2=425.92
CAS RN 57808-66-9
Related CAS RN
MDL Number MFCD00069256
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %

Data of Reference

mp 243°C(dec.)(lit.)

References

Reaxys-RN 903774
PubChem SID 135727073
Merck Index(14) 3418
RTECS# DE2275900
EC Number 260-968-7

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H360FD
  • :May damage fertility. May damage the unborn child.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

HS Number 2933998090

Application

Domperidone: A Peripherally Acting Dopamine D2 Receptor Antagonist

Domperidone is a peripherally acting dopamine D2 receptor antagonist with antiemetic properties similar to those of metoclopramide [M2218] . Unlike metoclopramide, however, domperidone does not readily cross the blood-brain barrier. Its antiemetic effect may be due to a combination of gastrokinetic effects and an antagonism of dopamine D2 receptor. Since the 2000s, the US Food and Drug Administration (FDA) have issued a warning about the cardiac safety of domperidone. (The product is for research purpose only.)

References

PubMed Literature

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