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Siramesine Hydrochloride
(CAS RN:224177-60-0 Product Number:I1090)

Structure

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Siramesine Hydrochloride
Synonym 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]-3H-spiro[isobenzofuran-1,4'-piperidine] Hydrochloride

General Information

Product Number I1090

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature <0°C
M.F. / M.W. C30H31FN2O·HCl=491.05
CAS RN 224177-60-0
Related CAS RN
MDL Number MFCD28144522
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Specification

Purity(HPLC) min. 98.0 area%
Melting point 223.0 to 227.0 deg-C
Elemental analysis(Nitrogen) gt. 5.20 to 5.80 %

References

Reaxys-RN 14640899

Transport Information

HS Number 2934999090

Application

Siramesine: A σ2 Opioid Receptor Agonist

Siramesine (Lu 28-179) is a σ2 opioid receptor agonist and was first developed as an agent for the treatment of anxiety.1) It was well tolerated and non-toxic in humans but the effect was not satisfactory.2) However, after the development stopped, it has been reported that siramesine induces the death of cancer cells in vitro by destabilizing lysosomes.3-6) (The product is for research purpose only.)

References

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