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N-Methyl Paroxetine
(CAS RN:110429-36-2 Product Number:M2645)

Structure

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N-Methyl Paroxetine

General Information

Product Number M2645

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Purity/Analysis Method >98.0%(GC)(T)
Storage Temperature <0°C
M.F. / M.W. C20H22FNO3=343.40
CAS RN 110429-36-2
Related CAS RN
MDL Number MFCD03788781
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 109.0 to 113.0 deg-C
Specific rotation [a]20/D -69.0 to -89.0 deg(C=0.01, MeOH)

References

Reaxys-RN 768178
PubChem SID 253662337

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2934999090

Application

N-Methyl paroxetine: A Synthetic Precursor of Paroxetine

N-Methyl paroxetine is a synthetic precursor of paroxetine hydrochloride hemihydrate [P1977] which is a 5-hydroxytryptamine (5-HT) uptake inhibitor.

References

  • Preparation of crystalline paroxetine hydrochloride hemihydrate for use as an antidepressant
    • R. D. Barnes, M. W. Wood-Kaczmar, J. E. Richardson, I. R. Lynch, P. C. Buxton, A. D. Curzons, Eur. Pat. Appl. 1987, EP 223403 A2.
  • Preparation of paroxetine from N-alkyl derivatives.
    • S.-z. Wang, Y. Matsumura, Eur. Pat. Appl. 1997, EP 810225 A1.

PubMed Literature

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