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Neostigmine Methyl Sulfate
(CAS RN:51-60-5 Product Number:N0447)

Structure

Neostigmine Methyl Sulfate
Synonym (3-Dimethylcarbamoyloxyphenyl)trimethylammonium Methyl Sulfate
Synonym (3-Hydroxyphenyl)trimethylammonium Methyl Sulfate Dimethylcarbamate

General Information

Product Number N0447

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Purity/Analysis Method >98.0%(N)
Storage Temperature
M.F. / M.W. C13H22N2O6S=334.39
CAS RN 51-60-5
Related CAS RN 59-99-4
MDL Number MFCD00011796
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(with Total Nitrogen) min. 98.0 %
Melting point 145.0 to 149.0 deg-C
Solubility in Water almost transparency

References

Reaxys-RN 3848275
PubChem SID 87573782
Merck Index(14) 6464
RTECS# CY1225000
EC Number 200-109-5

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H300
  • :Fatal if swallowed.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear eye protection.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P405
  • :Store locked up.

Transport Information

UN Number 2811
Class 6.1
Packing Group II
HS Number 2939790090

Application

Neostigmine Methyl Sulfate: A Competitive Cholinesterase Inhibitor

Neostigmine methyl sulfate, a synthetic physostigmine analog, is a competitive cholinesterase inhibitor. Unlike the plant alkaloid physostigmine [P0406], neostigmine methyl sulfate has a quaternary nitrogen, hence it more polar and does not cross the blood-brain barrier. Neostigmine methyl sulfate induces an increase in acetylcholine (ACh) in the synaptic cleft through reversible inhibition of its hydrolysis by acetylcholinesterase (AChE), and activates peripheral cholinergic nervous system. Neostigmine methyl sulfate used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as tubocurarine [C0433] (The product is for research purpose only.)

References

PubMed Literature

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