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Paliperidone
(CAS RN:144598-75-4 Product Number:P1897)

Structure

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Paliperidone
Synonym 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

General Information

Product Number P1897

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Purity/Analysis Method >97.0%(T)
Storage Temperature
M.F. / M.W. C23H27FN4O3=426.49
CAS RN 144598-75-4
Related CAS RN
MDL Number
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 95.0 area%
Purity(Nonaqueous Titration) min. 97.0 %

References

Reaxys-RN 8808385
PubChem SID 125307525
RTECS# UV1164720

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2934999090

Application

Paliperidone (9-Hydroxyrisperidone): A dopamine D2 and Serotonin 5-HT2 Receptors Antagonist

Paliperidone (another name: 9-hydroxyrisperidone), a benzisoxazole derivative, is acts as a dopamine type 2 (D2) and serotonin type 2 (5-HT2) receptors antagonist, and the major active metabolite of risperidone [R0087]. Similarly to risperidone, paliperidone has also affinity for α1- and α2-adrenergic, and H1 histaminergic receptors. Paliperidone has no affinity for cholinergic muscarinic or β1- and β2-adrenergic receptors. The pharmacological activity of the (+)- and (-)-paliperidone enantiomers is qualitatively and quantitatively similar in vitro. Risperidone is used as an antipsychotic agent with relatively few side effects. Recently, paliperidone extended-release formulation is developed for clinical use. (The product is for research purpose only.)

References

PubMed Literature

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