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Reserpine
(CAS RN:50-55-5 Product Number:R0007)

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Reserpine

General Information

Product Number R0007

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C33H40N2O9=608.69
CAS RN 50-55-5
Related CAS RN
MDL Number MFCD00005091
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Specific rotation [a]20/D -172 to -182 deg(C=1, DMF)

References

Reaxys-RN 102015
PubChem SID 87575589
Merck Index(14) 8145
RTECS# ZG0350000
EC Number 200-047-9

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H360FD
  • :May damage fertility. May damage the unborn child.
  • H370
  • :Causes damage to Nervous System.
  • H372
  • :Causes damage to Nervous System through prolonged or repeated exposure.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P260
  • :Do not breathe dust, fume, mist, vapours or spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P311
  • :If exposed or concerned: Call a POISON CENTER or doctor.

Transport Information

HS Number 2939790090

Application

Reserpine: A Central Nervous System Depressant and an Inhibitor of Multidrug Efflux Pumps in Bacteria

Reserpine is an alkaloid of rauwolfia sharing the yohimbine [Y0002] pentacyclic skeleton. Pharmacological studies have revealed that reserpine is a central nervous system depressant. Reserpine depletes stores of catecholamines (dopamine [A0305], noradrenaline [A0906] and adrenaline [A0173]) and 5-hydroxytryptamine [S0370] by inhibiting their accumulation in many organs, including the brain and adrenal medulla. The depression of the central nervous system results in a decreased heart rate and a lowering of arterial blood pressure.
In addition, some studies have reported that reserpine enhances the in vitro activity of fluoroquinolones, such as norfloxacin [N0817], ciprofloxacin [C2227, C2510] and sparfloxacin [S0840], against strains of Staphylococcus aureus expressing distinct efflux-related multidrug resistance pumps. (The product is for research purpose only.)

References

Reagen for myalgia model

References

  • Depletion and recovery of neuronal monoamine storage in rats of different ages treated with reserpine
    • F. Ponzio, G. Achilli, G. Calderini, P. Ferretti, C. Perego, G. Toffano, S. Algeri, Neurobiol. Aging. 1984, 5, 101.
  • Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia

Reagent for pain model

References

Reagent for schizophrenia model

References

PubMed Literature

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