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6-Thioguanine
(CAS RN:154-42-7 Product Number:T0212)

Structure

6-Thioguanine
Synonym 2-Amino-6-mercaptopurine
Synonym 6-Mercaptoguanine

General Information

Product Number T0212

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Purity/Analysis Method >95.0%(HPLC)
Storage Temperature
M.F. / M.W. C5H5N5S=167.19
CAS RN 154-42-7
Related CAS RN
MDL Number MFCD00233553
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 95.0 area%

References

Reaxys-RN 1074099
PubChem SID 87576202
Merck Index(14) 9337
RTECS# UP0740000
EC Number 205-827-2

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, eye protection.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2933998090

Application

6-Thioguanineis: A Cytotoxic Agent with Immunosuppressive and Antitumor Properties

T0212

6-Thioguanine (6-TG) is a cytotoxic agent with immunosuppressive and antitumor properties. In cell, 6-TG is converted to the active nucleotide metabolite by the enzyme hypoxanthine guanine phosphoribosyltransferase (HPRT), subsequently leading to inhibition of DNA/RNA synthesis.

References

PubMed Literature

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