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Kanamycin Monosulfate
(CAS RN:25389-94-0 Product Number:K0047)

Structure

Kanamycin Monosulfate
Synonym O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine Monosulfate

General Information

Product Number K0047

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Purity/Analysis Method >94.0%(N)
Storage Temperature
M.F. / M.W. C18H36N4O11·H2SO4=582.58
CAS RN 25389-94-0
Related CAS RN 59-01-8,8063-07-8
MDL Number MFCD00070253
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Specification

Appearance White to Almost white powder to crystal
Purity(with Total Nitrogen) min. 94.0 %
Specific rotation [a]20/D +112 to +123 deg(C=1, H2O)(calcd.on dried substance)
Drying loss max. 4.0 %

Data of Reference

mp 250°C(dec.)(lit.)

References

Beilstein 18(4)7631
Reaxys-RN 3874279
PubChem SID 87560322
Merck Index(14) 5281
RTECS# NZ3225030

Transport Information

HS Number 2941.90.1010

Application

Kanamycin: A Broad Spectrum Aminoglycoside Antibiotic and a Selective Reagent Genetically Engineered Cells

Kanamycin, an aminoglycoside antibiotic, was first isolated in 1957 from the bacterium Streptomyces kanamyceticus by Umezawa. Kanamycin has broad activity against Gram-negative bacteria and Gram-positive bacteria, including Mycobacterium tuberculosis. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Kanamycin is used in molecular biology as a selective reagent most commonly to isolate bacteria (e.g., Escherichia coli.) coupled to a gene coding for kanamycin resistance, which is one of the most frequently used selection markers for obtaining transgenic cells.

References

PubMed Literature

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