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(CAS RN:1450841-27-6 Product Number:B4228)



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Product Number B4228

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Purity/Analysis Method >90.0%(HPLC)
Storage Temperature
M.F. / M.W. C41H39N3O2=605.78
CAS RN 1450841-27-6
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Purity(HPLC) min. 90.0 area%
Specific rotation [a]20/D -173 to -183 deg(C=1, CHCl3)


PubChem SID 253659536

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HS Number 2934999090


An Efficient Bis(oxazolidine)pyridine Ligand Utilizing for the Asymmetric [3+2] Cycloaddition


Experimental Procedure:
Bis(oxazolidine)pyridine ligand (B4228, 0.0165 mmol) and Cu(OAc)2 (0.015 mmol) are added to a round flask containing a stir bar under Ar. CH2Cl2 (1 mL) is added to the flask and the mixture is stirred over 12 hours. To the resulting solution is added azomethine imine (0.15 mmol) at rt. After cooling to –40 °C, to the mixture is added ethyl propiolate (0.18 mmol). After stirring for 47 hours, the reaction mixture is purified by silica gel column chromatography (Et2O/Hexane=2/1 to Et2O) to afford the desired N,N-bicyclic pyrazolidinone derivative (99% yield, 94% ee).


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