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Allopurinol
(CAS RN:315-30-0 Product Number:A0907)

Structure

Allopurinol
Synonym 4-Hydroxypyrazolo[3,4-d]pyrimidine
Synonym 1H-Pyrazolo[3,4-d]pyrimidin-4-ol

General Information

Product Number A0907

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Purity/Analysis Method >98.0%(T)
Storage Temperature
M.F. / M.W. C5H4N4O=136.11
CAS RN 315-30-0
Related CAS RN
MDL Number MFCD00599413
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(Neutralization titration) min. 98.0 %
Solubility in 1mol/L NaOH almost transparency

Data of Reference

mp 384°C(lit.)

References

Beilstein 26(3/4)4298
Reaxys-RN 608611
PubChem SID 87562416
Merck Index(14) 279
RTECS# UR0785000
EC Number 206-250-9

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
  • H317
  • :May cause an allergic skin reaction.
Precautionary Statements
  • P261
  • :Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P302+P352+P333+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Take off contaminated clothing. And wash it before reuse.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2933998090

Application

Allopurinol: A Purine Inhibitor of Xanthine Oxidase (XO)

Allopurinol is a xanthine oxidase (XO) inhibitor which inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism. XO catalyzes the oxidative hydroxylation of hypoxanthine [H0311] to xanthine [X0004] and further catalyze the oxidation of xanthine to uric acid [U0018]. Hence, XO inhibitors can lower serum levels of uric acid. In additon, febuxostat [F0847] is a non-purine inhibitor of XO. Allopurinol, first synthesized as a potential antitumor agent, is nowadays a clinical useful XO inhibitor used in the treatment of gout and the prevention of tumor lysis syndrome. (The product is for research purpose only.)

References

PubMed Literature

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