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(S)-(+)-Camptothecin
(CAS RN:7689-03-4 Product Number:C1495)

Structure

(S)-(+)-Camptothecin

General Information

Product Number C1495

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Purity/Analysis Method >97.0%(HPLC)
Storage Temperature
M.F. / M.W. C20H16N2O4=348.36
CAS RN 7689-03-4
Related CAS RN
MDL Number MFCD00081076
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 97.0 area%
Purity(Nonaqueous Titration) min. 95.0 %
Specific rotation [a]20/D +37.0 to +42.0 deg(C=0.4, CHCl3:MeOHl=8:2)

References

Reaxys-RN 6075662
PubChem SID 87566492
Merck Index(14) 1735
RTECS# UQ0492000

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

UN Number 1544
Class 6.1
Packing Group III
HS Number 2939790090

Application

Camptothecin: The First Identified Topoisomerase-I Inhibitor

Camptothecin (CPT), a plant alkaloid with antitumor activity, was first isolated by Wall et al. in 1966 from the Chinese tree, Camptotheca acuminate. CPT shows strong anticancer activity against a wide range of experimental tumors, but also low water solubility and high toxicity (myelosuppression and hemorrhagic cystitis). Because of these disadvantages, various CPT derivatives have been discovered such as irinotecan hydrochloride [I0714] and topotecan. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death. (The product is for research purpose only.)

References

PubMed Literature

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