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10-Hydroxycamptothecin
(CAS RN:19685-09-7 Product Number:H1463)

Structure

10-Hydroxycamptothecin

General Information

Product Number H1463

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature <0°C
M.F. / M.W. C20H16N2O5=364.36
CAS RN 19685-09-7
Related CAS RN
MDL Number MFCD02093100
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 97.0 %

Data of Reference

mp 267°C(lit.)
[α]20D 35.3° (C=0.11,CH2Cl2:MeOH=4:1)(lit.)
λmax 382(lit.)

References

Reaxys-RN 3019077
PubChem SID 354335739
RTECS# UQ0491700

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301+H311+H331
  • :Toxic by inhalation, in contact with skin and if swallowed.
Precautionary Statements
  • P261
  • :Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P302+P352+P312+P361+P364
  • :IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or doctor if you feel unwell. Take off immediately all contaminated clothing and wash it before reuse.
  • P304+P340+P311
  • :IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER or doctor.

Transport Information

UN Number 1544
Class 6.1
Packing Group III
HS Number 2939790090

Application

10-Hydroxycamptothecin: An Inhibitor of Topoisomerase I with Antitumor Activity

10-hydroxycamptothecin (10-HCPT) is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. 10-HCPT, a member of the camptothecin family, interferes with DNA synthesis by inhibiting the enzyme topoisomerase-I, and has a broad spectrum of antitumor activity and less toxicity as a camptothecins.1,2) However, 10-HCPT is insoluble in both water and physiological acceptable organic solvents and tends to change into its carboxylate form, which shows minimal antitumor activity and several unpredictable side effects.3,4) Therefore, appropriate drug delivery systems (DDS) for 10-HPCT have been developed to improve the stability of its lactone form.5,6) 10-HCPT is also an important precursor for the synthesis of the clinical useful anticancer agents, such as irinotecan [I0714]. (The product is for research purpose only.)

References

PubMed Literature

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