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Nimesulide
(CAS RN:51803-78-2 Product Number:N0984)

Structure

Nimesulide
Synonym N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

General Information

Product Number N0984

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C13H12N2O5S=308.31
CAS RN 51803-78-2
Related CAS RN
MDL Number MFCD00079470
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 148.0 to 152.0 deg-C

Data of Reference

λmax 391(H2O)(lit.)

References

Reaxys-RN 2421175
PubChem SID 253662461
Merck Index(14) 6548
RTECS# PB0970000
EC Number 257-431-4

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
  • H361fd
  • :Suspected of damaging fertility. Suspected of damaging the unborn child.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2935909099

Application

Nimesulide: A Relatively Selective Inhibitor of Cyclooxygenase-2 (COX-2)

Nimesulide, a sulfonanilide compound, is a relatively selective inhibitor of cyclooxygenase-2 (COX-2) and is used as a non-steroidal anti-inflammatory drug (NSAID). Selective inhibition of COX-2 by NSAIDs may have less gastrointestinal toxicity, while inhibition of COX-1 is linked to gastrointestinal ulcer formation. In addition, nimesulide has some unique therapeutic and pharmacological activities. However, nimesulide induced hepatotoxicity is reported.

References

PubMed Literature

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