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Sulfasalazine
(CAS RN:599-79-1 Product Number:S0580)

Structure

Sulfasalazine
Synonym 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic Acid

General Information

Product Number S0580

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Purity/Analysis Method >95.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C18H14N4O5S=398.39
CAS RN 599-79-1
Related CAS RN
MDL Number MFCD00057363
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 95.0 area%
Purity(Neutralization titration) min. 95.0 %

Data of Reference

mp 246°C(dec.)(lit.)

References

Beilstein 22(5)8,433
Reaxys-RN 356241
PubChem SID 87560165
Merck Index(14) 8942
RTECS# VO6250000
EC Number 209-974-3

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H351
  • :Suspected of causing cancer.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

HS Number 2935909099

Application

Sulfasalazine: A Prodrug of 5-Aminosalicylic Acid (5-ASA), a NF-κB Inhibitor and an xCT Inhibitor

Sulfasalazine (salazosulfapyridin) is formed by combining sulfapyridine and salicylate with an azo bond. Sulfasalazine is split by intestinal bacteria to two main matabolites, sulfapyridine [S0071] and 5-aminosalicylic acid (5-ASA) [A0317], and the 5-ASA shows anti-inflammatory effects. Sulfasalazine is used as a gastrointestinal anti-inflammatory agent and is known as a potent inhibitor of NF-κB. Sulfasalazine is commonly used in the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease (CD) and rheumatoid arthritis (RA).
Recently, the antitumor effects of sulfasalazine have attracted attention. CD44v is an adhesion molecule expressed in cancer stem-like cells. CD44v interacts with xCT, a glutamate-cysteine transporter, keeping high levels of the intracellular reduced glutathione (GSH) which an important antioxidant and stabilizer in cell. Sulfasalazine works as an xCT inhibitor, and suppresses CD44v-dependent tumor growth and increases sensitivity to cytotoxic drugs. (The product is for research purpose only.)

References

PubMed Literature

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