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Tiaramide Hydrochloride
(CAS RN:35941-71-0 Product Number:T3176)

Structure

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Tiaramide Hydrochloride
Synonym 5-Chloro-3-[[4-(2-hydroxyethyl)piperazin-1-yl]carbonylmethyl]-2-benzothiazolinone Hydrochloride

General Information

Product Number T3176

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Purity/Analysis Method >98.0%(T)
Storage Temperature
M.F. / M.W. C15H18ClN3O3S·HCl=392.30
CAS RN 35941-71-0
Related CAS RN 32527-55-2
MDL Number MFCD01702832
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 97.0 area%
Purity(Nonaqueous Titration) min. 98.0 %

Data of Reference

mp 160°C(lit.)

References

Reaxys-RN 6081227
PubChem SID 253660473
Merck Index(14) 9424
RTECS# TL7050000
EC Number 252-802-7

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear eye protection.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2934999090

Application

Tiaramide Hydrochloride: A Non-Acidic and Non-Steroidal Anti-Inflammatory Agent with No Inhibiting Action of COX

Tiaramide hydrochloride, a benzothiazolinone derivative, is a non-acidic and non-steroidal antiinflammatory drug (NSAID). It has almost the same antiinflammatory activity and analgesic effect as benzydamine hydrochloride [B3751], but does not inhibit cyclooxygenase (COX). (The product is for research purpose only.)

References

  • Antiinflammatory activity of tiaramide hydrochloride, 4-[(5-chloro-2-oxo-3-benzothiazolinyl)acetyl]-1-piperazineethanol hydrochloride
    • K. Tsurumi, Y. Hiramatsu, M. Nozaki, M. Hayashi, H. Fujimura, Arzneim.-Forsch. 1972, 22, 716.
  • Pharmacological actions of tiaramide hydrochloride, a new antiinflammatory drug
    • K. Tsurumi, Y. Hiramatsu, M. Nozaki, M. Hayashi, H. Fujimura, Arzneim.-Forsch. 1972, 22, 724.
  • Central and peripheral analgesic action of nonacidic nonsteroidal anti-inflammatory drugs in mice and rats
    • H. Nakamura, A. Shimoda, K. Ishii, T. Kadokawa, Arch. Int. Pharmacodyn. Ther. 1986, 282, 16.
  • Preparation and evaluation of beads made of different calcium alginate compositions for oral sustained release of tiaramide
  • High performance liquid chromatographic determination of epirizole and tiaramide in pharmaceutical preparations

PubMed Literature

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