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3'-Azido-3'-deoxythymidine
(CAS RN:30516-87-1 Product Number:A2052)

Structure

3'-Azido-3'-deoxythymidine
Synonym 1-(3-Azido-2,3-dideoxy-β-D-ribofuranosyl)thymine
Synonym Azidothymidine
Synonym AZT
Synonym Zidovudine

General Information

Product Number A2052

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Purity/Analysis Method >98.0%(T)
Storage Temperature
M.F. / M.W. C10H13N5O4=267.25
CAS RN 30516-87-1
Related CAS RN
MDL Number MFCD00006536
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(Neutralization titration) min. 98.0 %
Melting point 122.0 to 126.0 deg-C
Specific rotation [a]20/D +43.0 to +51.0 deg(C=1, H2O)

References

Reaxys-RN 3595791
PubChem SID 87559740
Merck Index(14) 10123
RTECS# XP2072000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H351
  • :Suspected of causing cancer.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

HS Number 2940000080

Application

Synthesis of Novel Potent Anti-HIV Compounds via Click Chemistry

References

Synthesis of Antitumor Compounds via Click Chemistry

References

Zidovudine (AZT): a Nucleotide Reverse Transcriptase Inhibitor (NRTI)

3'-Azido-2',3'-dideoxythymidine (AZT, Zidovudine) is a nucleotide reverse transcriptase inhibitor (NRTI). It shows activity against human immunodeficiency virus (HIV). In 1985, AZT was found to inhibit the HIV in vitro (Mitsuya et al.). AZT, after conversion to AZT-5'-triphosphate (AZT-TP) by cellular enzymes, inhibits HIV-reverse transcriptase (HIV-RT).

References

PubMed Literature

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