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Chelerythrine Chloride
(CAS RN:3895-92-9 Product Number:C3584)

Structure

Chelerythrine Chloride
Synonym 1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium Chloride

General Information

Product Number C3584

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Purity/Analysis Method >97.0%(HPLC)
Storage Temperature <0°C
M.F. / M.W. C21H18ClNO4=383.83
CAS RN 3895-92-9
Related CAS RN
MDL Number MFCD00060717
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 97.0 area%
Water max. 12.0 %

Data of Reference

mp 195°C(lit.)
λmax 320(MeOH)(lit.)

References

Reaxys-RN 3898541
RTECS# FL9200000
EC Number 223-444-9

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Application

Chelerythrine Chloride: A Cell-Permeable Protein Kinase C

Chelerythrine chloride is a benzophenanthridine alkaloid isolated from roots of F. zanthoxyloides.1) Chelerythrine chloride is a cell-permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase.2) It has been reported that chelerythrine chloride induces apoptotic cell death of cancer cells.3-6)

References

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