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Famciclovir
(CAS RN:104227-87-4 Product Number:F0842)

Structure

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Famciclovir
Synonym 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol Diacetate

General Information

Product Number F0842

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C14H19N5O4=321.34
CAS RN 104227-87-4
Related CAS RN
MDL Number MFCD00866964
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Specification

Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 103.0 to 107.0 deg-C

Data of Reference

λmax 310(EtOH)(lit.)

References

Reaxys-RN 4208403
PubChem SID 160871205
RTECS# TY3164000

Transport Information

HS Number 2933599590

Application

Famciclovir: A Prodrug of Penciclovir

Famciclovir is a prodrug of penciclovir [P2164] which is an anti-herpesvirus agent. It has demonstrated inhibitory activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and varicella zoster virus (VZV). The viral thymidine kinase (TK) phosphorylates penciclovir to a monophosphate form. Subsequently, the monophosphate s converted to penciclovir triphosphate by cellular kinases. The triphosphate inhibits virus DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, famciclovir interfere with herpes viral DNA synthesis and replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to famciclovir (penciclovir), which has extremely low toxicity for human cell. (The product is for research purpose only.)

References

PubMed Literature

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