Home >   Products   >  Advanced Search

Gemcitabine Hydrochloride
(CAS RN:122111-03-9 Product Number:G0367)

Structure

Gemcitabine Hydrochloride
Synonym 2'-Deoxy-2',2'-difluorocytidine
Synonym dFdC

General Information

Product Number G0367

* Items available from stock in Japan will be delivered in 10 business days.
* Please contact us if you need further information.
(Sales Dept Tel: +32 (0)3 735 07 00 E-mail: Sales-EU@TCIchemicals.com)
* To send your quote request for bulk quantities, please click on the “Request Bulk Quotation” button. Please note that for some of our products we cannot offer bulk quantities.
* TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

Purity/Analysis Method >98.0%(HPLC)(N)
Storage Temperature
M.F. / M.W. C9H11F2N3O4·HCl=299.66
CAS RN 122111-03-9
Related CAS RN 95058-81-4
MDL Number MFCD01735988
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Specific rotation [a]20/D +46.0 to +49.0 deg(C=1, H2O)

Data of Reference

mp 292°C(lit.)
λmax 268(H2O)(lit.)

References

Reaxys-RN 5386970
PubChem SID 125307627
Merck Index(14) 4386
RTECS# HA3840000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
  • H361fd
  • :Suspected of damaging fertility. Suspected of damaging the unborn child.
  • H373
  • :May cause damage to Lung through prolonged or repeated exposure.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P260
  • :Do not breathe dust, fume, mist, vapours or spray.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.

Transport Information

HS Number 2934999090

Application

Gemcitabine Hydrochloride: A Fluorinated Deoxycytidine Analog with Antitumor Activity

Gemcitabine [G0544] and its hydrochloride are fluorinated deoxycytidine analogs with antitumor activity against solid tumors. Once inside the cell, gemcitabine is rapidly phosphorylated by deoxycytidine kinase to form the active metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCDP inhibits ribonucleotide reductase, which is responsible for producing the deoxynucleotides required for DNA synthesis and repair. dFdCTP can be incorporated into DNA, leading to inhibition of DNA synthesis. On the other hand, a concomitant treatment with gemcitabine and cisplatin [D3371] is used for the treatment of several different types of cancer. Cisplatin acts by formation of platinum (Pt)-DNA adducts; gemcitabine acts by dFdCTP incorporation into DNA, subsequently leading to inhibition of exonuclease and DNA repair. (The product is for research purpose only.)

References

Page Top