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Irinotecan Hydrochloride Trihydrate
(CAS RN:136572-09-3 Product Number:I0714)

Structure

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Irinotecan Hydrochloride
Synonym CPT-11 Trihydrate

General Information

Product Number I0714

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C33H38N4O6·HCl·3H2O=623.15(as Anhydrous)
CAS RN 136572-09-3
Related CAS RN 100286-90-6,97682-44-5
MDL Number MFCD01765731
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %(calcd.on anh.substance)
Specific rotation [a]20/D +22.0 to +26.0 deg(C=1, methanol)
Water 7.0 to 10.0 %

Data of Reference

bp 257°C(lit.)

References

Reaxys-RN 4838283
PubChem SID 87560270
Merck Index(14) 5091
RTECS# DW1060750

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H372
  • :Causes damage to Blood, Digestive Tract through prolonged or repeated exposure.
Precautionary Statements
  • P260
  • :Do not breathe dust, fume, mist, vapours or spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P312+P330
  • :IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. Rinse mouth.
  • P314
  • :Get medical advice or attention if you feel unwell.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

HS Number 2933998090

Application

Irinotecan hydrochloride (CPT-11): A Water Soluble Topoisomerase-I Inhibitor with Enhanced Activity

Irinotecan hydrochloride (CPT-11) is a derivative of 7-ethylcamptothecin (SN-22) [E0781] or Camptothecin (CPT) [C1495]. Irinotecan hydrochloride has greater water solubility and enhanced topoisomerase-I inhibitory activity than theirs. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) [E0748] by a carboxylesterase-converting enzyme. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death. (The product is for research purpose only.)

References

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