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Neostigmine Bromide
(CAS RN:114-80-7 Product Number:N0358)

Structure

Neostigmine Bromide
Synonym (3-Dimethylcarbamoyloxyphenyl)trimethylammonium Bromide
Synonym (3-Hydroxyphenyl)trimethylammonium Bromide Dimethyl Carbamate

General Information

Product Number N0358

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Purity/Analysis Method >99.0%(T)
Storage Temperature
M.F. / M.W. C12H19BrN2O2=303.20
CAS RN 114-80-7
Related CAS RN 59-99-4
MDL Number MFCD00011795
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(Nonaqueous Titration) min. 99.0 %(after drying)
Solubility in Water almost transparency
Drying loss max. 1.0 %

References

Beilstein 13(3)939
Reaxys-RN 3640678
PubChem SID 87573710
Merck Index(14) 6464
RTECS# BR3150000
EC Number 204-054-8

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, eye protection.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2924297099

Application

Neostigmine Bromide: A Competitive Cholinesterase Inhibitor

Neostigmine bromide, a synthetic physostigmine analog, is a competitive cholinesterase inhibitor. Unlike the plant alkaloid physostigmine [P0406], neostigmine bromide has a quaternary nitrogen, hence it more polar and does not cross the blood-brain barrier. Neostigmine bromide induces an increase in acetylcholine (ACh) in the synaptic cleft through reversible inhibition of its hydrolysis by acetylcholinesterase (AChE), and activates peripheral cholinergic nervous system. Neostigmine bromide used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as tubocurarine [C0433]. (The product is for research purpose only.)

References

PubMed Literature

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