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Nitazoxanide
(CAS RN:55981-09-4 Product Number:N1031)

Structure

Nitazoxanide
Synonym 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
Synonym NTZ

General Information

Product Number N1031

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C12H9N3O5S=307.28
CAS RN 55981-09-4
Related CAS RN
MDL Number MFCD00416599
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 198.0 to 202.0 deg-C

Data of Reference

λmax 416(Phosphate buffer sol.)(lit.)

References

Reaxys-RN 1225475
PubChem SID 354333058
Merck Index(14) 6567
RTECS# VN7830000
EC Number 259-931-8

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, eye protection.
  • P301+P312+P330
  • :IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2934100090

Application

Nitazoxanide: A Thiazolide Antiprotozoal and Antiviral Agent

Nitazoxanide is originally developed as a thiazolide antiprotozoal agent that shows excellent in vitro activity against a variety of microorganisms, including a broad range of protozoa and helminths. Nitazoxanide is a prodrug, and following oral administration in animals, nitazoxanide is rapidly hydrolyzed to an active metabolite, tizoxanide (desacetyl-nitazoxanide) by esterase. The antiprotozoal activity of tizoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Recently, antiviral activity of nitazoxanide against a broad range of other RNA and DNA viruses such as hepatitis B virus, hepatitis C virus and influenza virus has been recognized in in vitro systems. Nitazoxanide is synergistic with neuraminidase inhibitors, and also inhibits the replication of a broad range of viruses. (The product is for research purpose only.)

References

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