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Quinine
(CAS RN:130-95-0 Product Number:Q0028)

Structure

Quinine

General Information

Product Number Q0028

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Purity/Analysis Method >98.0%(T)
Storage Temperature
M.F. / M.W. C20H24N2O2=324.42
CAS RN 130-95-0
Related CAS RN
MDL Number MFCD00198096
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Appearance White to Almost white powder to crystal
Purity(HPLC) min. 96.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 174.0 to 179.0 deg-C
Specific rotation [a]20/D -160 to -170 deg(C=2, EtOH)
Solubility in Methanol almost transparency

References

Beilstein 23(2)416
Reaxys-RN 5293630
PubChem SID 87575561
Merck Index(14) 8061
F&F 9,403
RTECS# VA6020000
EC Number 205-003-2

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H317
  • :May cause an allergic skin reaction.
  • H319
  • :Causes serious eye irritation.
  • H334
  • :May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statements
  • P261
  • :Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P280
  • :Wear protective gloves, eye protection.
  • P284
  • :Wear respiratory protection.
  • P302+P352+P333+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Take off contaminated clothing. And wash it before reuse.
  • P304+P340+P342+P311
  • :IF INHALED: Remove person to fresh air and keep comfortable for breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2939200000

Application

Quinine, an Antimalarial Substance

  Quinine is one of the alkaloids which is included in the bark of cinchona tree and has been researched since 19th century.1) It has an anti-malarial activity2-4) and is considered to inhibit heme polymerase of plasmodium and to indicate toxicity to plasmodium. There are other antimalarial substances such as chloroquine diphosphate [C2301], hydroxychloroquine sulfate [H1306] and artemisinin [A2118]. (The product is for research purpose only)

References

Asymmetric Tandem Michael Addition/Oxidation of Pyrazolones with p-Benzoquinone Using Cinchona Alkaloid Catalysts

B0089,Q0028

Typical Procedure:
p-Benzoquinone (42.6 mg, 0.4 mmol) and quinine (1.3 mg, 2 mol%) are dissolved in 1,2-dichloroethane (2 mL). The solution is stirred at 25 °C for 10 min, after which a 4-substituted pyrazol-5-one (0.2 mmol) is added to the mixture. The solution is stirred at 25 °C for 24 h. Next, the solvent is removed under reduced pressure. The residue is directly subjected to column chromatography (petroleum ether/EtOAc = 10:1–6:1) to afford the desired product.

References

PubMed Literature

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