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Ritonavir
(CAS RN:155213-67-5 Product Number:R0116)

Structure

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Ritonavir

General Information

Product Number R0116

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Purity/Analysis Method >98.0%(HPLC)(N)
Storage Temperature
M.F. / M.W. C37H48N6O5S2=720.95
CAS RN 155213-67-5
Related CAS RN
MDL Number MFCD00927142
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 122.0 to 127.0 deg-C
Specific rotation [a]20/D +7.0 to +10.0 deg(C=2,MeOH)

References

Reaxys-RN 7680098
PubChem SID 253660208
Merck Index(14) 8238
RTECS# XA5310000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302+H312+H332
  • :Harmful by inhalation, in contact with skin and if swallowed.
Precautionary Statements
  • P261
  • :Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing.
  • P302+P352+P312+P362+P364
  • :IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or doctor if you feel unwell. Take off contaminated clothing and wash it before reuse.
  • P304+P340+P312
  • :IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER or doctor if you feel unwell.

Transport Information

HS Number 2934100090

Application

Ritonavir: a Booster of Other Protease Inhibitors

Ritonavir was originally developed as an inhibitor of HIV protease inhibitor (PI). Ritonavir is currently exclusively used as a pharmacokinetic enhancer (booster) of other protease inhibitors, due to ritonavir's potent inhibition of the cytochrome P 450 3A4 (CYP3A4), an enzyme that is responsible for metabolizing most HIV PIs.

References

PubMed Literature

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