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Tizanidine Hydrochloride
(CAS RN:64461-82-1 Product Number:T2527)

Structure

Tizanidine Hydrochloride
Synonym 5-Chloro-4-[(4,5-dihydro-1H-imidazol-2-yl)amino]-2,1,3-benzothiadiazole Hydrochloride

General Information

Product Number T2527

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C9H8ClN5S·HCl=290.17
CAS RN 64461-82-1
Related CAS RN 51322-75-9
MDL Number MFCD00798231
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %

Data of Reference

mp 280°C(lit.)

References

Reaxys-RN 6022764
PubChem SID 87560328
Merck Index(14) 9485
RTECS# DK9910000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, eye protection.
  • P301+P312+P330
  • :IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2934999090

Application

Tizanidine Hydrochloride: A Centrally Acting α2-Adrenergic Receptor Agonist

Tizanidine hydrochloride is a centrally acting α2-adrenergic receptor agonist and presumably reduces spasticity of the muscles by increasing presynaptic inhibition of motor neurons. Tizanidine is mainly metabolized by cytochrome P450 (CYP) 1A2. Tizanidine is widely used to manage spasticity caused by multiple sclerosis (MS), acquired brain injury and spinal cord injury (SCI). In addition, some fast dissolving tablets of tizanidine hydrochloride have been developed. (The product is for research purpose only.)

References

PubMed Literature

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