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Tiagabine Hydrochloride
(CAS RN:145821-59-6 Product Number:T3165)

Structure

Tiagabine Hydrochloride

General Information

Product Number T3165

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Purity/Analysis Method >99.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C20H25NO2S2·HCl=412.00
CAS RN 145821-59-6
Related CAS RN 115103-54-3
MDL Number MFCD07369025
Packaging and Container
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Specification

Purity(HPLC) min. 99.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 189.0 to 194.0 deg-C
Specific rotation [a]20/D -9.0 to -12.0 deg(C=1, H2O)

References

Reaxys-RN 6378452
PubChem SID 253662389
Merck Index(14) 9417
RTECS# TM6128245

Transport Information

HS Number 2934999090

Application

Tiagabine hydrochloride: A Potent and Selective Anticonvulsant GABA Uptake Inhibitor of Neuronal GABA Transporter

γ-Aminobutyric acid (GABA) [A0282] is considered to be the major inhibitory neuro-transmitter in the brain and loss of GABA inhibition has been clearly implicated in. Tiagabine hydrochloride is a potent and selective anticonvulsant GABA uptake inhibitor of the principal neuronal GABA transporter 1 (GAT-1) in the cortex and hippocampus. Tiagabine elevates synaptic GABA levels by inhibiting GAT-1. (The product is for research purpose only.)

References

PubMed Literature

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