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L-Tetrahydropalmatine
(CAS RN:483-14-7 Product Number:T3311)

Structure

L-Tetrahydropalmatine
Synonym (13aS)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine

General Information

Product Number T3311

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature
M.F. / M.W. C21H25NO4=355.43
CAS RN 483-14-7
Related CAS RN
MDL Number MFCD03265591
Packaging and Container
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Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 96.0 %
Melting point 140.0 to 144.0 deg-C
Specific rotation [a]20/D -278.0 to -298.0 deg(C=1, EtOH)

Data of Reference

λmax 280(lit.)

References

Reaxys-RN 96288
PubChem SID 253661327
RTECS# HQ1792500

Transport Information

HS Number 2933998090

Application

A Plant Alkaloid Effective in Multidrug Resistant Cancer Cells

L-Tetrahydropalmatine (L-THP or l-THP), the active enantiomer of THP [T3650], is an alkaloid found in several plant species such as Corydalis and Stephania. Corydalis Tuber (Corydalis yanhusuo) containing L-THP has been used for traditional Chinese pain medicine. Since L-THP antagonizes dopamine D1/D2 receptors and acts on dopamine D3 receptors, as well as α-adrenergic and serotonin receptors, it may have utility for treating opioid addiction.1,2) Furthermore, it has been reported that L-THP shows activity against antineoplastic resistant cancer cells.3) (The product is for research purpose only.)

References

PubMed Literature

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