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Vidarabine Monohydrate
(CAS RN:24356-66-9 Product Number:V0098)

Structure

Vidarabine
Synonym Adenine 9-β-D-Arabinofuranoside Monohydrate
Synonym Ara-A Monohydrate
Synonym 9-(β-D-Arabinofuranosyl)adenine Monohydrate

General Information

Product Number V0098

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C10H13N5O4·H2O=267.25(as Anhydrous)
CAS RN 24356-66-9
Related CAS RN 5536-17-4
MDL Number MFCD00065471
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %(calcd.on dried substance)
Specific rotation [a]20/D -2.0 to -4.0 deg(C=1, DMF)
Drying loss 5.0 to 7.0 %

Data of Reference

mp 253°C(lit.)

References

Beilstein 26(3/4)3598
Reaxys-RN 93029
PubChem SID 87560128
Merck Index(14) 9976
RTECS# AU6200000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H361fd
  • :Suspected of damaging fertility. Suspected of damaging the unborn child.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

HS Number 2940000080

Application

Vidarabine: An Arabinosyladenine with Ant-Virus and Anti-Cancer Activities

Vidarabine (arabinosyladenine, ara-A) is a synthetic purine nucleoside, and was first synthesized by Lee et al. in 1960. Vidarabine was originally intended as an anti-cancer agent, while the anti-viral activity against herpesvirus and vaccinia virus was reported by Rudder et al. in 1965. And also the activity against varicella-zoster virus was reported by Miller et al. in 1968. Vidarabine had a broad-spectrum activity against DNA viruses but little activity against RNA viruses. Vidarabine is converted to the active form vidarabine triphosphate (ara-ATP) which inhibits viral DNA polymerase activity in vitro and in vivo.

References

PubMed Literature

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