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N-tert-Butyl-5-methylisoxazolium Perchlorate
(CAS RN:10513-45-8 Product Number:B0832)

Structure

N-tert-Butyl-5-methylisoxazolium Perchlorate
Synonym Woodward's Reagent L

General Information

Product Number B0832

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Purity/Analysis Method >98.0%(HPLC)(N)
Storage Temperature
M.F. / M.W. C8H14ClNO5=239.65
CAS RN 10513-45-8
Related CAS RN
MDL Number MFCD00011960
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Appearance White to Light yellow to Light red powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 119.0 to 122.0 deg-C

References

Reaxys-RN 5202574
PubChem SID 87563816
EC Number 234-048-0

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H272
  • :May intensify fire; oxidizer.
Precautionary Statements
  • P210
  • :Keep away from heat.
  • P220
  • :Keep/Store away from clothing/combustible materials.
  • P221
  • :Take any precaution to avoid mixing with combustibles.
  • P280
  • :Wear protective gloves, eye protection.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

UN Number 1479
Class 5.1
Packing Group III
HS Number 2934999090

Application

Woodward’s Reagent L: A Condensing Agent

B0832

Experimental procedure1):
Under nitrogen, N-tert-butyl-5-methylisoxazolium perchlorate (240 mg, 1 mmol) is added to a mixture of 3-quinoline carboxylic acid (173 mg, 1 mmol) and triethylamine (140 μL, 1 mmol) in DMF (2 mL). The mixture is stirred at room temperature for 4 h and then poured on iced water (50 mL). The precipitate is collected, washed with water and dried. The intermediate ester 1 (131 mg, 0.44 mmol) is isolated in 44% yield as a yellow powder. Then the product (110 mg, 0.36 mmol) in DMF (3 mL) is added to a freshly prepared guanidine 2 (123 mg, 0.39 mmol) and the mixture is stirred at 140 °C for 2 h. The solvent is evaporated under reduced pressure. Water (10 mL) is added to the residue, and after 12 h at 4 °C, the precipitate formed is filtered, washed with water, and dried to obtain compound 3 in 85% yield.

References

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