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Bendamustine Hydrochloride Hydrate
(CAS RN:3543-75-7 Product Number:B4033)

Structure

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Bendamustine Hydrochloride
Synonym 5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazole-2-butyric Acid Hydrochloride Hydrate

General Information

Product Number B4033

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C16H21Cl2N3O2·HCl·xH2O=394.72(as Anhydrous)
CAS RN 3543-75-7
Related CAS RN 16506-27-7
MDL Number MFCD16879055
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %(calcd.on anh.substance)
Melting point 165.0 to 169.0 deg-C
Water 3.0 to 6.0 %

References

Reaxys-RN 6031568
PubChem SID 172089039
Merck Index(14) 1034
RTECS# DE1590000

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
  • H341
  • :Suspected of causing genetic defects.
  • H351
  • :Suspected of causing cancer.
  • H361fd
  • :Suspected of damaging fertility. Suspected of damaging the unborn child.
  • H371
  • :May cause damage to Bone Marrow.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P260
  • :Do not breathe dust, fume, mist, vapours or spray.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P308+P311
  • :If exposed or concerned: Call a POISON CENTER or doctor.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2933998090

Application

Bendamustine Hydrochloride: A Unique Cytotoxic Chemotherapeutic Agent

Bendamustine hydrochloride, an antitumor alkylating agent, was first synthesized in 1963 in the German Democratic Republic. It is a unique cytotoxic chemotherapeutic agent with structural similarities to alkylating agents and antimetabolites containing a purine-like benzimidazole ring, but which is non-cross-resistant with alkylating agents. Bendamustine form covalent bonds with electron-rich nucleophilic moieties, resulting in interstrand DNA crosslinks. This covalent linkage can lead to cell death via several pathways. Recently, bendamustine is re-evaluated as an antitumor agent, and widely used for the treatment of indolent non-Hodgkin's lymphoma (NHL) and mantle cell lymphoma (MCL). (The product is for research purpose only.)

References

PubMed Literature

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