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3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine
(CAS RN:28230-32-2 Product Number:D2039)

Structure

3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine
Synonym 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
Synonym 3-Hydroxy-4-ketobenzotriazine

General Information

Product Number D2039

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C7H5N3O2=163.14
CAS RN 28230-32-2
Related CAS RN
MDL Number MFCD00042803
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Appearance White to Light yellow to Light orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %

References

Reaxys-RN 609382
EC Number 248-916-1

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2933998090

Application

An Efficient Additive for Condensation Reactions

D2039

Experimental procedure: 1 (60.6 mg, 0.21 mmol), 2 (85.5 mg, 0.20 mmol) and 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine (0.22 mmol) are dissolved in 1 mL of TFE/CHCl3 (1:3 v/v). To the mixture is added a solution of EDC (34.2 mg, 0.22 mmol) of in 1 mL of TFE/CHCl3 (1:3 v/v), and the whole mixture is stirred at rt overnight. The resulting mixture is diluted with 25 mL of EtOAc, washed with 1 mol/L HCl (2 × 10 mL), 10% NaHCO3 (2 × 10 mL), and brine (2 × 10 mL), and dried over MgSO4. After removal of solvent, the solid is then stirred with 2 mL of 50% TFA in a dichloromethane solution for 2 h to deblock the Boc-group. The TFA and CH2Cl2 are then removed in vacuo, 20 mL of anhydrous ether is added to the oily residue, and the mixture is stored overnight. The white precipitate which has separated is collected by filtration and washed with ether to afford 3 (96% over 2 steps).

References

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