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Dimethylthiophosphinoyl Chloride
(CAS RN:993-12-4 Product Number:D2159)


Dimethylthiophosphinoyl Chloride
Synonym Chlorodimethylphosphine Sulfide
Synonym Dimethylphosphinothioyl Chloride

General Information

Product Number D2159

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Purity/Analysis Method >97.0%(GC)
Storage Temperature 0-10°C
M.F. / M.W. C2H6ClPS=128.55
CAS RN 993-12-4
Related CAS RN
MDL Number MFCD00014454
Packaging and Container
  • Product Details
  • Safety & Regulations


Appearance Colorless to Almost colorless clear liquid
Purity(GC) min. 97.0 %

Data of Reference

bp 78°C/15mmHg(lit.)


Reaxys-RN 906761
PubChem SID 87568600
EC Number 213-606-7


Signal Word Danger
Hazard Statements
  • H290
  • :May be corrosive to metals.
  • H302+H312+H332
  • :Harmful by inhalation, in contact with skin and if swallowed.
  • H314
  • :Causes severe skin burns and eye damage.
Precautionary Statements
  • P260
  • :Do not breathe dusts or mists.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P330+P331+P310
  • :IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or doctor.
  • P303+P361+P353+P310+P363
  • :IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Immediately call a POISON CENTER or doctor. Wash contaminated clothing before reuse.
  • P304+P340+P310
  • :IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER or doctor.
  • P305+P351+P338+P310
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor.

Transport Information

UN Number 3265
Class 8
Packing Group II
HS Number 2930909899


A Condensing Reagent for the Peptide Synthesis in Alcohol Solvents

Experimental procedure1): A solution of Cbz-Asn-OH (79.8 mg, 0.3 mmol) and triethylamine (41.8 μL, 0.3 mmol) in methanol (2.6 mL) is cooled to -20 °C, and treated with a solution of Dimethylthiophosphinoyl Chloride (Mpt-Cl, 38 mg, 0.3 mmol) in methanol (0.9 mL), and the mixture stirred for 20 min. The solution is added to a solution of the tetrapeptide (1, 133.3 mg, 0.3 mmol) and triethylamine (41.8 μL, 0.3 mmol) in methanol (7.0 mL) and water (3.0 mL) at -20 °C. After the mixture has been stirred for 40 minutes the Cbz-Asn-OMpt solution and triethylamine (0.3 mmol each) are added and the stirring continued at -20 °C for 2 h and at 0 °C for 48 h. The precipitate is filtered and washed with chloroform, ethanol, water, and ether, and dried to give the pentapeptide (2, 173.7 mg, 84 %).

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