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5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
(CAS RN:53-85-0 Product Number:D4292)

Structure

5,6-Dichlorobenzimidazole 1-beta-D-Ribofuranoside
Synonym 5,6-Dichlorobenzimidazole Riboside
Synonym 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole
Synonym DRB

General Information

Product Number D4292

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Purity/Analysis Method >98.0%(HPLC)(N)
Storage Temperature <0°C
M.F. / M.W. C12H12Cl2N2O4=319.14
CAS RN 53-85-0
Related CAS RN
MDL Number MFCD00036785
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Specification

Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 220.0 to 224.0 deg-C
Specific rotation [a]20/D -66.0 ~ -68.0 deg(C=2, Pyridine)

Data of Reference

λmax 296(lit.)

References

Reaxys-RN 39123
PubChem SID 253660379
RTECS# DD7310000

Transport Information

HS Number 2934999090

Application

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB): A Selective Inhibitor of Transcription Elongation by RNA Polymerase II

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB) is a selective inhibitor of transcription elongation by RNA polymerase II, and then it inhibits of mRNA synthesis in eukaryotic cells. The inhibition can trigger p53-dependent apotosis of tumor cells. DRB can also inhibit HIV transcription by targeting elongation enhanced by the HIV-encoded transactivator (Tat).

References

PubMed Literature

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