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N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis]
(CAS RN:21715-90-2 Product Number:H0528)



General Information

Product Number H0528

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Purity/Analysis Method >99.0%(T)
Storage Temperature
M.F. / M.W. C9H9NO3=179.18
CAS RN 21715-90-2
Related CAS RN
MDL Number MFCD00167583
Packaging and Container
  • Product Details
  • Safety & Regulations


Appearance White to Almost white powder to crystal
Purity(Neutralization titration) min. 99.0 %
Melting point 167.0 to 171.0 deg-C
Solubility in Water almost transparency


Reaxys-RN 181264
PubChem SID 87570917
F&F 6,290
EC Number 244-538-6


Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2928009090


An Efficient Additive for Condensation Reactions

Experimental procedure: to a solution of 1 (1 mmol) in anhydrous DMF (10 mL) is added N-Hydroxy-5-norbornene-2,3-dicarboximide (1.1 mmol) and DIC (1.1 mmol) in one portion. Reaction mixture is stirred for additional 5 min at 0 °C and then L-ProNH2(2, 1 mmol) is added. The reaction is stirred for additional 36 h at 4 °C. Solvent is evaporated under reduced pressure and the crude product is purified by column chromatography using MeOH/CH2Cl2 (15:85) as eluant to afford 3 as a white solid in 77% yield.


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