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2-Methyl-5-nitroimidazole-1-ethanol
(CAS RN:443-48-1 Product Number:M0924)

Structure

2-Methyl-5-nitroimidazole-1-ethanol
Synonym Metronidazole

General Information

Product Number M0924

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Purity/Analysis Method >99.0%(GC)(T)
Storage Temperature
M.F. / M.W. C6H9N3O3=171.16
CAS RN 443-48-1
Related CAS RN
MDL Number MFCD00009750
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(GC) min. 99.0 %
Purity(Nonaqueous Titration) min. 99.0 %
Melting point 159.0 to 163.0 deg-C
Solubility in hot Methanol almost transparency

References

Reaxys-RN 611683
PubChem SID 87572910
Merck Index(14) 6157
RTECS# NI5600000
EC Number 207-136-1

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H351
  • :Suspected of causing cancer.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

HS Number 2933299090

Application

Metronidazole: A Nitroimidazole Antibiotic against Protozoans and Anaerobic Bacteria

2-Methyl-5-nitroimidazole-1-ethanol (metronidazole) is a synthetic nitroimidazole antibiotic such as azomycin [N0891] and dimetridazole [D1564]. Metronidazole has a limited spectrum of activity that encompasses various protozoans and most Gram-negative and Gram-positive anaerobic bacteria. Metronidazole is bactericidal through toxic metabolites (hydroxyl radicals) which cause bacterial DNA strand breakage. Metronidazole is active against Helicobacter pylori, however resistance to metronidazole is high. Thus, the combination of lansoprazole [L0233] or omeprazole [O0359] (as a proton pump inhibitor), amoxicillin [A2099] and metronidazole is used for the eradication of Helicobacter pylori.

References

PubMed Literature

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