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Milnacipran Hydrochloride
(CAS RN:101152-94-7 Product Number:M2133)

Structure

Milnacipran Hydrochloride
Synonym cis-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride

General Information

Product Number M2133

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C15H22N2O·HCl=282.81
CAS RN 101152-94-7
Related CAS RN 92623-85-3
MDL Number MFCD00901293
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %

Data of Reference

mp 181°C(dec.)(lit.)

References

Reaxys-RN 6078861
PubChem SID 125307702
Merck Index(14) 6194
RTECS# GZ1014010

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2924297099

Application

Milnacipran hydrochloride: A Selective Serotonin Noradrenaline Reuptake Inhibitor (SNRI)

Milnacipran hydrochloride is a selective serotonin noradrenaline reuptake inhibitor (SNRI) which acts by inhibiting noradrenaline (norepinephrine) and serotonin (5-hydroxytrytamine; 5-HT) reuptake at presynaptic sites. Milnacipran has unique characteristics that distinguish it from the other SNRIs, venlafaxine [V0110] and duloxetine [D4223], such as inhibition of noradrenaline reuptake with approximately 3-fold higher potency in vitro than serotonin. Milnacipran has no significantt affinity for other neurotransmitter receptors, such as serotonergic, α- and β-adrenergic, muscarinic, histamine, dopamine, opioid, benzodiazepine, and γ-aminobutyric acid (GABA) receptors in vitro. Milnacipran does not inhibit the activity of human monoamine oxidases (MAO-A and MAO-B) or acetylcholinesterase. (The product is for research purpose only.)

References

PubMed Literature

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