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4-Nitrophenol
(CAS RN:100-02-7 Product Number:N0220)

Structure

4-Nitrophenol

General Information

Product Number N0220

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Purity/Analysis Method >99.0%(GC)
Storage Temperature
M.F. / M.W. C6H5NO3=139.11
CAS RN 100-02-7
Related CAS RN
MDL Number MFCD00007331
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Appearance White to Light yellow to Green powder to crystal
Purity(GC) min. 99.0 %
Melting point 112.0 to 116.0 deg-C
Solubility in EtOH almost transparency
Transition interval(pH) (very pale yellow)4.8 to 7.6(yellow)

Data of Reference

bp 279°C(lit.)

References

Beilstein 6,226
Reaxys-RN 1281877
PubChem SID 87573588
Merck Index(14) 6620
F&F 2,297
RTECS# SM2275000
EC Number 202-811-7

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
  • H312+H332
  • :Harmful by inhalation and in contact with skin.
  • H315
  • :Causes skin irritation.
  • H317
  • :May cause an allergic skin reaction.
  • H319
  • :Causes serious eye irritation.
  • H370
  • :Causes damage to organs.
  • H372
  • :Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements
  • P260
  • :Do not breathe dust, fume, mist, vapours or spray.
  • P280
  • :Wear protective gloves, protective clothing, eye protection.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P302+P352+P312+P362+P364
  • :IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or doctor if you feel unwell. Take off contaminated clothing and wash it before reuse.
  • P304+P340+P312
  • :IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER or doctor if you feel unwell.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

UN Number 1663
Class 6.1
Packing Group III
HS Number 2908990030

Application

Condensing Agent

Experimental procedure: Boc-Gly-OH (1.98 kg, 11.3 mol) and 4-nitrophenol (1.73 kg, 12.43 mol, 1.1 eq.) are dissolved in dry dioxane (25 L), a solution of DCC (2.8 kg, 13.56 mol, 1.2 eq.) in dry dioxane (10 L) is added and the mixture is stirred for 8-10 h. After cooling for 2 h, the precipitate is removed and the filtrate is used directly for next reaction without purification. The mixture of glycine (0.94 kg, 12.43 mol, 1.1 eq.) and NaHCO3 (1.05 kg, 12.43 mol, 1.1 eq.) in H2O (10 L) is slowly added to the solution of Boc-Gly-ONp in dioxane (25 L). The solution is stirred at about 25 °C for 7 h and then evaporated under reduced pressure. The residue is acidified to a pH 2-3 with 10% citric acid and extracted with EtOAc (3 × 20 L). The organic phase is successively washed with brine (20 L), dried, and evaporated to give Boc-Gly-Gly-OH (2.37 kg, 90%) as a white crystal.

References

PubMed Literature

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