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(CAS RN:95-54-5 Product Number:P0168)


Synonym 1,2-Diaminobenzene

General Information

Product Number P0168

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Purity/Analysis Method >98.0%(GC)(T)
Storage Temperature
M.F. / M.W. C6H8N2=108.14
CAS RN 95-54-5
Related CAS RN
MDL Number MFCD00007721
Packaging and Container
  • Product Details
  • Safety & Regulations


Appearance White to Light yellow to Dark green powder to crystal
Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 100.0 to 105.0 deg-C

Data of Reference

bp 265°C(lit.)


Colour Index 76010
Beilstein 13(4)38
Reaxys-RN 606074
PubChem SID 87574418
Merck Index(14) 7284
F&F 8,393
RTECS# SS7875000
EC Number 202-430-6


Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
  • H312+H332
  • :Harmful by inhalation and in contact with skin.
  • H317
  • :May cause an allergic skin reaction.
  • H319
  • :Causes serious eye irritation.
  • H341
  • :Suspected of causing genetic defects.
  • H351
  • :Suspected of causing cancer.
  • H410
  • :Very toxic to aquatic life with long lasting effects.
Precautionary Statements
  • P261
  • :Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P302+P352+P312+P362+P364
  • :IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or doctor if you feel unwell. Take off contaminated clothing and wash it before reuse.
  • P304+P340+P312
  • :IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER or doctor if you feel unwell.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

UN Number 1673
Class 6.1
Packing Group III
HS Number 2921511910


One-pot Synthesis of Benzodiazepin Derivatives via Three-component Reaction



Synthesis of Benzimidazole Using Gold’s Reagent

A dry, three-necked, round-bottomed flask is equipped with a condenser, thermometer, magnetic stirrer and is placed under a nitrogen atmosphere. Into the flask is placed 100 mL of dry 1,4-dioxane along with 5.4 g (0.05 mol) of 1,2-phenylenediamine and 9.9 g (0.061 mol) of Gold’s reagent. The mixture is refluxed overnight, cooled to room temperature and 4.1 g (0.05 mol) of anhydrous sodium acetate and 2 mL of glacial acetic acid are added. The resulting mixture is refluxed for 3 hours, cooled to room temperature and the solvent is removed in vacuo. The residue is taken up in chloroform (100 mL), extracted with a saturated, aqueous solution of sodium bicarbonate (3 x 50 mL) and dried over anhydrous magnesium sulfate. After removing the drying agent by filtration, the chloroform extract is concentrated in vacuo to leave a solid which is collected by vacuum filtration with the aid of a small amount (15 mL) of water. The resulting benzimidazole amounts to 3.7 g (63% yield).


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