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Mitoxantrone
(CAS RN:65271-80-9 Product Number:M3133)

Structure

Mitoxantrone
Synonym 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthracene-9,10-dione
Synonym 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone

General Information

Product Number M3133

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Purity/Analysis Method >97.0%(HPLC)
Storage Temperature -20°C
M.F. / M.W. C22H28N4O6=444.49
CAS RN 65271-80-9
Related CAS RN 70476-82-3
MDL Number MFCD00242942
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 97.0 area%
Purity(Nonaqueous Titration) min. 96.0 %
Melting point 170.0 to 174.0 deg-C

Data of Reference

λmax 670(MeOH)(lit.)

References

Reaxys-RN 2795126
Merck Index(14) 6217
RTECS# CB5748500

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H351
  • :Suspected of causing cancer.
  • H411
  • :Toxic to aquatic life with long lasting effects.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P273
  • :Avoid release to the environment.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P391
  • :Collect spillage.
  • P405
  • :Store locked up.

Transport Information

UN Number 3077
Class 9
Packing Group III
HS Number 2922500090

Application

Mitoxantrone: A Synthetic Anthracycline Antitumor Agent with Improved Tolerability

Mitoxantrone and its dihydrochloride [M3110] are synthetic anthracycline antitumor agents that are structurally similar to doxorubicin hydrochloride [D4193] and daunorubicin hydrochloride [D4532]. Mitoxantrones intercalate into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. .Mitoxantrones also inhibit DNA repair by inhibiting topoisomerase II which results in fragmentation of DNA. Mitoxantrones display an improved tolerability profile compared with doxorubicin and other anthracyclines, but cross-resistance with the anthracyclines has been demonstrated. (The product is for research purpose only.)

References

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