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1-Adamantanamine Hydrochloride
(CAS RN:665-66-7 Product Number:A0588)

Structure

1-Adamantanamine Hydrochloride
Synonym 1-Adamantylamine Hydrochloride
Synonym Amantadine Hydrochloride
Synonym 1-Aminoadamantane Hydrochloride

General Information

Product Number A0588

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Purity/Analysis Method >99.0%(T)
Storage Temperature
M.F. / M.W. C10H17N·HCl=187.71
CAS RN 665-66-7
Related CAS RN 768-94-5
MDL Number MFCD00074723
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(Nonaqueous Titration) min. 99.0 %
Purity(Argentmetric Titration) min. 99.0 %
Solubility in Water almost transparency

References

Reaxys-RN 4198854
PubChem SID 87562172
RTECS# AU4375000
EC Number 211-560-2

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, eye protection.
  • P301+P312+P330
  • :IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2921309990

Application

1-Adamantanamine Hydrochloride: A Dopamine Receptor Agonist and an Anti-Influenza A Virus Agent

1-Adamantanamine hydrochloride and its free base [A2318] are dopamine receptor agonists and anti-influenza A virus agents, similarly rimantadine hydrochloride [R0070]. 1-Amantadine was originally developed as an antiviral agent. One day, a single patient noticed relief in her Parkinson’s disease symptoms after taking amantadine for a flu infection, and this observation led to a new drug indication.1)
These mechanisms of action are not fully understood. However, there is evidence to suggest that 1-adamantanamine act as a dopamine receptor agonist by enhancing the synthesis and release of dopamine from nerve cells and delaying the reuptake into synaptic vesicles.2,3)
In addition, 1-adamantanamine inhibits the replication of influenza A viruses by preventing the release of infectious viral RNA into the host cell nucleus by interfering with the function of the transmembrane of the viral M2 protein.4,5) (The product is for research purpose only.)

References

PubMed Literature

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