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Acyclovir
(CAS RN:59277-89-3 Product Number:A1915)

Structure

Acyclovir
Synonym Aciclovir
Synonym Acycloguanosine
Synonym 9-[(2-Hydroxyethoxy)methyl]guanine

General Information

Product Number A1915

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature
M.F. / M.W. C8H11N5O3=225.21
CAS RN 59277-89-3
Related CAS RN
MDL Number
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 94.0 %

Data of Reference

mp 262°C(lit.)

References

Reaxys-RN 1219402
PubChem SID 87559875
Merck Index(14) 146
RTECS# UP0791400
EC Number 261-685-1

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear eye protection.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2933998090

Application

Acyclovir: An Antiherpesvirus Agent

Acyclovir, an acyclic guanine nucleoside analog developed by Elion and Hitchings, is an antiherpesvirus agent like penciclovir [P2164]. Valacyclovir [V0111] is a prodrug of acyclovir. Acyclovir is active against most species in the herpesvirus family. It depends on the activity of the viral enzyme thymidine kinase (TK) to convert the agent to a monophosphate form and subsequently interfere with viral DNA replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to acyclovir, which has extremely low toxicity for human cell. The spectrum of activity of acyclovir against human herpesviruses is similar to that of penciclovir, both compounds having good activity against herpes simplex viruses types 1 and 2 (HSV-1, HSV-2), varicella-zoster virus (VZV), and Epstein-Barr virus (EBV). Like penciclovir, acyclovir has slight activity against cytomegalovirus (CMV).

References

PubMed Literature

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