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Adefovir Dipivoxil
(CAS RN:142340-99-6 Product Number:A2414)

Structure

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Adefovir Dipivoxil
Synonym 9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine

General Information

Product Number A2414

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature <0°C
M.F. / M.W. C20H32N5O8P=501.48
CAS RN 142340-99-6
Related CAS RN
MDL Number MFCD00869897
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Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 99.0 to 103.0 deg-C

References

Reaxys-RN 7060608
PubChem SID 135727110
Merck Index(14) 151
RTECS# UA2459362

Transport Information

HS Number 2933599590

Application

Studies of Antiviral Activity

References

  • Synthesis, Oral Bioavailability Determination, and in vitro Evaluation of Prodrugs of the Antiviral Agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)
  • Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates
    • R. V. Srinivas, B. L. Robbins, M. C. Connelly, Y. F. Gong, N. Bischofberger, A. Fridland, Antiviral Chem. Chemother. 1993, 37, 2247.
  • Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine
    • J. E. Starrett Jr., D. R. Tortolani, M. J. M. Hitchcock, J. C. Martin, M. M. Mansuri, Antiviral Res. 1992, 19, 267.

PubMed Literature

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