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(CAS RN:128-09-6 Product Number:C0291)


Synonym NCS

General Information

Product Number C0291

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Purity/Analysis Method >98.0%(T)
Storage Temperature
M.F. / M.W. C4H4ClNO2=133.53
CAS RN 128-09-6
Related CAS RN
MDL Number MFCD00005511
Packaging and Container
  • Product Details
  • Safety & Regulations


Purity(Iodometric Titration) min. 98.0 %
Melting point 146.0 to 151.0 deg-C
Solubility in hot Methanol almost transparency


Beilstein 21,380
Reaxys-RN 113915
PubChem SID 87565445
Merck Index(14) 2164
F&F 10,94
RTECS# UY1013500
EC Number 204-878-8


Signal Word Danger
Hazard Statements
  • H290
  • :May be corrosive to metals.
  • H302
  • :Harmful if swallowed.
  • H314
  • :Causes severe skin burns and eye damage.
Precautionary Statements
  • P260
  • :Do not breathe dusts or mists.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P330+P331+P310
  • :IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or doctor.
  • P303+P361+P353+P310+P363
  • :IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Immediately call a POISON CENTER or doctor. Wash contaminated clothing before reuse.
  • P304+P340+P310
  • :IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER or doctor.
  • P305+P351+P338+P310
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor.

Transport Information

UN Number 3261
Class 8
Packing Group II
HS Number 2925199590


A Method for the Synthesis of Acyclic Haloamines with Ring Opening of Cyclic Amines


Experimental procedure: To a vial, Piv-protected amine (1 eq.), AgNO3 (4 eq.), (NH4)2S2O8 (4 eq.), and NCS or NBS (4 eq.) is added and dissolved in 1:9 acetone:water (0.2 M). The resulting mixture is stirred at room temperature. After 30 minutes, the reaction mixture is partitioned between EtOAc and H2O and separated. The aqueous layer is extracted with EtOAc in triplicate and the combined organic layers concentrated in vacuo. The crude mixture is then purified over silica column eluting with an EtOAc:Hex. Mixture to afford the desired haloamine product.


PubMed Literature

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