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Clozapine
(CAS RN:5786-21-0 Product Number:C2547)

Structure

Clozapine
Synonym 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

General Information

Product Number C2547

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Purity/Analysis Method >98.0%(GC)(T)
Storage Temperature
M.F. / M.W. C18H19ClN4=326.83
CAS RN 5786-21-0
Related CAS RN
MDL Number MFCD00153785
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 183.0 to 187.0 deg-C

References

Reaxys-RN 764984
PubChem SID 135726987
Merck Index(14) 2423
RTECS# HP1750000
EC Number 227-313-7

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, eye protection.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2933998090

Application

Clozapine: A Dibenzodiazepine Agent with Effects on Various Receptors

Clozapine is a dibenzodiazepine “atypical” antipsychotic agent. The precise mechanism of actions is not fully understood. However, it has been reported that the therapeutic efficacy of clozapine is mediated through antagonism of the serotonin type 2A (5-HT2A) receptors. Clozapine also act as an antagonist at adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors. (The product is for research purpose only.)

References

PubMed Literature

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