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3,5-Dimethyl-1-adamantanamine Hydrochloride
(CAS RN:41100-52-1 Product Number:D3608)

Structure

3,5-Dimethyl-1-adamantanamine Hydrochloride
Synonym 1-Amino-3,5-dimethyladamantane Hydrochloride
Synonym Memantine Hydrochloride

General Information

Product Number D3608

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Purity/Analysis Method >98.0%(N)(T)
Storage Temperature
M.F. / M.W. C12H21N·HCl=215.77
CAS RN 41100-52-1
Related CAS RN 19982-08-2
MDL Number MFCD00214336
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(with Total Nitrogen) min. 98.0 %
Purity(Argentmetric Titration) min. 98.0 %

Data of Reference

mp 292°C(lit.)

References

Reaxys-RN 7937891
PubChem SID 87559918
Merck Index(14) 5806
EC Number 255-219-6

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2921309990

Application

Memantine Hydrochloride: A Moderate-Affinity and Uncompetitive N-Methyl-D-Aspartate (NMDA) Receptor Antagonist

Memantine hydrochloride is a moderate-affinity and uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. NMDA receptor (NMDAR) is a subtype of glutamate receptor, and very important for controlling synaptic plasticity and memory function. Persistent activation of central nervous system NMDAR by the excitatory amino acid glutamate has been hypothesized to contribute to the symptomatology of Alzheimer’s disease. Memantine binds preferentially in moderate to the NMDAR-operated cation channels, blocks current flow through the NMDARs, and controls the activity of the NMDARs. Therefore, memantine is used for the treatment of Alzheimer’s disease. (The product is for research purpose only.)

References

PubMed Literature

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