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(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
(CAS RN:863329-66-2 Product Number:D4823)

Structure

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
Synonym PSI-6206

General Information

Product Number D4823

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature <0°C
M.F. / M.W. C10H13FN2O5=260.22
CAS RN 863329-66-2
Related CAS RN
MDL Number MFCD27918669
Packaging and Container
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Specification

Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Specific rotation [a]20/D +87.0 to +92.0 deg(C=1,MeOH)

References

Reaxys-RN 10267735
PubChem SID 253661201

Transport Information

HS Number 2934999090

Application

A Selective Nucleoside Polymerase Inhibitor of Hepatitis C Virus (HCV)

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (other name: PSI-6206 or β-D-2'-deoxy-2'-fluoro-2'-C-methyluridine) is a selective nucleoside polymerase inhibitor of hepatitis C virus (HCV) replication that targets the NS5B polymerase. Recently, to improve pharmacokinetic properties for clinical use, some prodrugs of the 5'-phosphate derivative of PSI-6206 have been developed. In addition, PSI-6206 is an active metabolite of PSI-6130 (β-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine).

References

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