Ethosuximide
（CAS RN：77-67-8 Product Number：E0746）
Structure
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| Synonym | 2-Ethyl-2-methylsuccinimide |
|---|
Specification
| Appearance | White to Almost white powder to crystal |
|---|---|
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 48.0 to 52.0 deg-C |
Data of Reference
| bp | 150°C/12mmHg(lit.) |
|---|
GHS
| Pictogram |
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| Signal Word | Warning |
| Hazard Statements |
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| Precautionary Statements |
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Transport Information
| HS Number | 2925199590 |
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Application
Ethosuximide: A Specific T-Type Ca2+ Channel Inhibitor
Ethosuximide is a specific T-type Ca2+ channel inhibitor, and is presumed to reduce these low threshold T-type Ca2+ currents in thalamic neurons. Ethosuximide prevents the burst activity of thalamic neurons that is required for synchronous activation of cerebral cortical cells. Meanwhile, ethosuximide does not have any effect on GABA-mediated inhibition. Ethosuximide is effective only in absence seizures, a symptom of epilepsy. (The product is for research purpose only.)
References
- Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons
- Effects of ethosuximide, a T-type Ca2+channel blocker, on dorsal horn neuronal responses in rats
- Ethosuximide: from bench to bedside (a review)
- Ethosuximide (a review)
- Liquid-chromatographic determination of six antiepileptic drugs and two metabolites in microsamples of human plasma
View History
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