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Published TCIMAIL newest issue No.198
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CAS RN: 77-67-8 | Product Number: E0746
Ethosuximide
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Purity: >98.0%(GC)(T)
Synonyms:
- 2-Ethyl-2-methylsuccinimide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
£27.00
|
1 | 22 |
|
| 25G |
£105.00
|
Contact Us | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E0746 |
Purity / Analysis Method 
|
>98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__7H__1__1NO__2 = 141.17 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 77-67-8 |
| Reaxys Registry Number | 117054 |
| PubChem Substance ID | 87559573 |
| Merck Index (14) | 3748 |
| MDL Number | MFCD00072123 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 48.0 to 52.0 °C |
Properties (reference)
| Melting Point | 51 °C |
| Boiling Point | 150 °C/12 mmHg |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 201-048-7 |
| RTECS# | WN2800000 |
Transport Information:
| HS Number | 2925199590 |
Application
Ethosuximide: A Specific T-Type Ca2+ Channel Inhibitor
Ethosuximide is a specific T-type Ca2+ channel inhibitor, and is presumed to reduce these low threshold T-type Ca2+ currents in thalamic neurons. Ethosuximide prevents the burst activity of thalamic neurons that is required for synchronous activation of cerebral cortical cells. Meanwhile, ethosuximide does not have any effect on GABA-mediated inhibition. Ethosuximide is effective only in absence seizures, a symptom of epilepsy. (The product is for research purpose only.)
References
- Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons
- Effects of ethosuximide, a T-type Ca2+channel blocker, on dorsal horn neuronal responses in rats
- Ethosuximide: from bench to bedside (a review)
- Ethosuximide (a review)
- Liquid-chromatographic determination of six antiepileptic drugs and two metabolites in microsamples of human plasma
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