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Ethosuximide
(CAS RN:77-67-8 Product Number:E0746)

Structure

Ethosuximide
Synonym 2-Ethyl-2-methylsuccinimide

General Information

Product Number E0746

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Purity/Analysis Method >98.0%(GC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C7H11NO2=141.17
CAS RN 77-67-8
Related CAS RN
MDL Number MFCD00072123
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(GC) min. 98.0 %
Purity(Neutralization titration) min. 98.0 %
Melting point 48.0 to 52.0 deg-C

Data of Reference

bp 150°C/12mmHg(lit.)

References

Beilstein 21(5)9,595
Reaxys-RN 117054
PubChem SID 87559573
Merck Index(14) 3748
RTECS# WN2800000
EC Number 201-048-7

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P312+P330
  • :IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. Rinse mouth.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

HS Number 2925199590

Application

Ethosuximide: A Specific T-Type Ca2+ Channel Inhibitor

Ethosuximide is a specific T-type Ca2+ channel inhibitor, and is presumed to reduce these low threshold T-type Ca2+ currents in thalamic neurons. Ethosuximide prevents the burst activity of thalamic neurons that is required for synchronous activation of cerebral cortical cells. Meanwhile, ethosuximide does not have any effect on GABA-mediated inhibition. Ethosuximide is effective only in absence seizures, a symptom of epilepsy. (The product is for research purpose only.)

References

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