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(CAS RN:13311-84-7 Product Number:F0663)


Synonym 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide
Synonym 4'-Nitro-3'-(trifluoromethyl)isobutyranilide

General Information

Product Number F0663

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Purity/Analysis Method >98.0%(GC)
Storage Temperature
M.F. / M.W. C11H11F3N2O3=276.22
CAS RN 13311-84-7
Related CAS RN
MDL Number MFCD00072009
Packaging and Container
  • Product Details
  • Safety & Regulations


Purity(GC) min. 98.0 %
Melting point 110.0 to 114.0 deg-C


Reaxys-RN 2157663
PubChem SID 87560202
Merck Index(14) 4208
RTECS# UG5700000
EC Number 236-341-9


Signal Word Danger
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
  • H361fd
  • :Suspected of damaging fertility. Suspected of damaging the unborn child.
  • H370
  • :Causes damage to Liver.
Precautionary Statements
  • P260
  • :Do not breathe dust, fume, mist, vapours or spray.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P308+P311
  • :If exposed or concerned: Call a POISON CENTER or doctor.

Transport Information

HS Number 2924297099


Flutamide: A Non-Steroidal Androgen Receptor Antagonist

Flutamide (SCH 13521) and bicalutamide [B3206] are non-steroidal androgen receptor antagonists with antiandrogenic activity. Testosterone [T0027], the most important androgen, converted to 5α-dihydrotestosterone (DHT) [A0462] by 5α-reductase type 2 which reduces the 4,5-double bond of testosterone in prostate cells. DHT has two or three times greater androgen receptor (AR) affinity than testosterone. Upon DHT binding, the AR undergoes a conformational change and releases heat shock proteins (HSPs), resulting in mRNA expression and prostate cell proliferation. Flutamide is rapidly metabolized by hydroxylation of the side chain to primary active form 2-hydroxyflutamide [H1600]. Subsequently, 2-hydroxyflutamide acts as a potent and highly selective competitive antagonist of the AR, blocks the conversion of testosterone to DHT, and inhibits the proliferation of prostate cells. Flutamide and bicalutamide are used for the treatment of prostate cancer and other androgen-dependent conditions. (The product is for research purpose only.)


PubMed Literature

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