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Hydroxyurea
(CAS RN:127-07-1 Product Number:H0310)

Structure

Hydroxyurea

General Information

Product Number H0310

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Purity/Analysis Method >97.0%(N)
Storage Temperature
M.F. / M.W. CH4N2O2=76.06
CAS RN 127-07-1
Related CAS RN
MDL Number MFCD00007943
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(with Total Nitrogen) min. 97.0 %

References

Beilstein 3,95
Reaxys-RN 1741548
PubChem SID 87570732
Merck Index(14) 4848
RTECS# YT4900000
EC Number 204-821-7

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H340
  • :May cause genetic defects.
  • H361fd
  • :Suspected of damaging fertility. Suspected of damaging the unborn child.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2928009090

Application

Hydroxyurea (or hydroxycarbamide): A Ribonucleotide Reductase Inhibitor

Hydroxyurea (or hydroxycarbamide), a hydroxylated molecule of urea [U0077][U0073], is classified as an antitumor antimetabolite. Hydroxyurea inhibits deoxynucleotide and DNA synthesis by blocking the cellular enzyme ribonucleotide reductase, which is responsible for producing the deoxynucleotides required for DNA synthesis and repair, producing cell death in S phase (the phase of DNA synthesis). Recently, two effects of hydroxyurea have been reported: hydroxyurea increases the level of fetal hemoglobin, leading to a reduction in the incidence of vaso-occlusive crises in sickle cell anemia, and hydroxyurea inhibits human immunodeficiency virus-type 1 (HIV-1) DNA synthesis. (The product is for research purpose only.)

References

PubMed Literature

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