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4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical
(CAS RN:2226-96-2 Product Number:H0865)


4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl
Synonym 4-Hydroxy-TEMPO Free Radical
Synonym TEMPOL Free Radical

General Information

Product Number H0865

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Purity/Analysis Method >98.0%(GC)
Storage Temperature
M.F. / M.W. C9H18NO2=172.25
CAS RN 2226-96-2
Related CAS RN
MDL Number MFCD00006478
Packaging and Container
  • Product Details
  • Safety & Regulations


Purity(GC) min. 98.0 %
Purity(Iodometric Titration) min. 97.0 %
Melting point 69.0 to 75.0 deg-C
Solubility in Methanol very faint turbidity


Reaxys-RN 11328213
PubChem SID 87571222
Merck Index(14) 9141
F&F 9,247
RTECS# TN8991000
EC Number 218-760-9


Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, eye protection.
  • P301+P312+P330
  • :IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2933399990


Aerobic Oxidation of Alcohols Using 4-Hydroxy-TEMPO Adsorbed on Silica Gel

Typical Procedure:
Preparation of [4-hydroxy-TEMPO + NaCl]/SiO2
Silica gel (9.77 g) is added to the solution of 4-hydroxy-TEMPO (0.17 g) and NaCl (0.06 g) in water (50 mL), and the mixture is stirred at room temperature for half an hour. The water is removed by rotary evaporator under reduced pressure (65 °C and 40 mbar).

Aerobic Oxidation of Alcohols
A mixture of alcohols (2.0 mmol), Fe(NO3)3•9H2O (5–8 mol%) and [4-hydroxy-TEMPO + NaCl]/SiO2 [(0.1 + 0.1) mmol/g, 1.0 g] is stirred in DCE (5 mL) under air (1 atm) at room temperature, and then the used supported reagents are removed by filtration. Product yield is determined by GLC analysis using n-dodecane as an internal standard.


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